PK/PD Modeling Assistant
Lets an agent analyse drug concentration data, fit PK/PD models, and run exploratory dosing simulations
- Repository
- K-Dense-AI/scientific-agent-skills
- Stars
- 55,780
- Licence
- MIT
- Files
- 15 files
What it does
When installed, this skill teaches an AI agent how to work on pharmacokinetic (how the body processes a drug) and pharmacodynamic (what the drug does to the body) problems. The agent follows a structured workflow: it checks units and definitions, computes exposure measures such as AUC, Cmax and half-life from concentration-time data, fits simple individual compartmental models, and documents its assumptions. It is explicitly framed as exploratory and does not provide clinical dosing advice or regulatory certification.
Great for
- Pharmacology or clinical pharmacology students learning NCA and compartmental modelling
- Researchers who want a scripted, assumption-documented first pass on concentration-time data
- Modellers preparing popPK, PK/PD or bioequivalence analysis plans before using licensed software
Skip it if
- Patient-specific dosing decisions, since the skill states it does not recommend patient doses and its outputs are not clinical evidence (risk of misuse in care)
- Regulatory submissions, since the skill explicitly does not certify submissions; results still need validation by qualified specialists
- Production population PK estimation, since the bundled fitting is individual-only and not NLME estimation
Try asking
- “Compute AUC, Cmax, half-life and clearance from this concentration-time CSV with a 100 mg oral dose”
- “Fit 1-, 2- and 3-compartment models to my IV bolus data and compare them by AIC”
- “Calculate steady-state AUCtau and Cavg from a sampled dosing interval”
- “Plan a bioequivalence study sample size and outline a popPK analysis plan”
Install in 3 steps
- 1
Download the skill
The ZIP contains the 15 original files, the MIT licence and an attribution note.
pkpd-modeling.zip - 2
Add it to your agent
Claude Code (all projects)
mkdir -p ~/.claude/skills && unzip pkpd-modeling.zip -d ~/.claude/skills/Claude Code / Agent SDK (this project only)
mkdir -p .claude/skills && unzip pkpd-modeling.zip -d .claude/skills/Claude apps (web/desktop): Settings → Capabilities → Skills → Upload skill, and choose the ZIP.
- 3
Ask for the task
No special command needed — the agent reads the skill's description and loads it when your request matches. Try one of the prompts above.
Get better results
- Provide clean input columns (id, time, conc, and dose details) and state units explicitly, since mg/L versus ng/mL errors are a common pitfall the skill warns about
- Read the findings printed to stderr and the exit code (1 means findings), not just the table output
- Treat outputs as exploratory and have a pharmacometrics specialist review any result before it informs decisions
What's inside
- assets/nca-reporting-checklist.md
- assets/popk-analysis-plan.md
- references/antimicrobial-and-tdm.md
- references/bioequivalence.md
- references/dataset-standards.md
- references/ddi-and-qt.md
- references/nca-conventions.md
- references/pbpk.md
- references/pd-and-exposure-response.md
- references/population-pk.md
- references/regulatory-guidance.md
- references/software-ecosystem.md
- references/source-ledger.md
- references/special-populations.md
- SKILL.md
Redistributed unmodified from K-Dense-AI/scientific-agent-skills under the MIT licence. The assessment was drafted with AI from the skill's files on 2026-10-29. Skills can instruct your agent to run code — read SKILL.md and any scripts before installing.